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10.3889/oamjms.2015.111 Open Access

However, the use of animal models is expensive, requires a lot of time and expertise, has low throughput potential, poses ethical issues, but most importantly, these models often do not correlate to human systems (Barr-Sinoussi and Montagutelli 2015)

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Its not currently approved by the FDA for women in the United States, but doctors sometimes prescribe it off-label, usually as a cream or gel applied to the skin