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doi: 10.1186/s12889-019-7587-2 185 LuppinoFSde WitLMBouvyPFStijnenTCuijpersPPenninxBWet al

The study also found that incidence of gout, a painful form of arthritis, was 6.6% in the group not taking the drug and 7.4% in the GLP-1 group

Proteins are fragile

In its Phase 2 obesity trial it produced the largest average body-weight reductions yet reported for a once-weekly agent but every gram of that effect was built on a slow, deliberate dose-escalation schedule