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Health improvements: Better blood sugar, lower blood pressure, or improved cholesterol can happen before significant weight loss appears on the scale

Fatima Stanford, an obesity medicine specialist at Massachusetts General Hospital, said shed welcome any shifts in weight-loss programs that facilitate more "comprehensive strategies." Typical doctor-patient chats about obesity have followed a predictable pattern, Stanford said: "'Hey, you know what you should do: Eat less and exercise more.' And then the patient does that, comes back six months later and is about the same." Although lifestyle changes aren't ineffective, she added, "unfortunately the brain has hormones that bring you back to normal." Stanford said that given that, she doesn't fear an overreliance on prescriptions like Ozempic and Wegovy and instead thinks such treatments can push more patients toward healthier lifestyles

According to a recent detailed review published in the medical journal, Gastroenterology , sustained GLP-1receptor activation is associated with weight loss in both preclinical and clinical studies

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