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-Challenge: Increased market competition between biosimilar manufacturers and originator biologic companies

International Journal for Vitamin and Nutrition Research, 83 (2), 92100

Mianserin, a tetracyclic antidepressant, has been shown to inhibit tumor growth in SW480 cells in vitro and in vivo through ASCT2 inhibition ( 3.3 Glutamate dehydrogenase (GLUD/GDH) inhibitors Glutamine is enzymatically converted to glutamate by glutaminase, and further conversion of glutamate to -KG is facilitated by GLUD through oxidative deamination (Yoo et al., 2020)