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OZEMPIC: Risks, Benefits, and Natural Alternatives to GLP-1 Weight-Loss Drugs The New York Times bestselling author who taught us How Not to Die, How Not to Diet, and How Not to Age brings us Risks, Benefits, and Natural Alternatives to GLP-1 Weight-Loss Drugs

Scand J Gastroenterol (2014) 49(6):6819.10.3109/00365521.2014.898326 14 WorthingtonJJ

They are all small molecules which act as reversible competitive inhibitors of the catalytic activity of DPP-4 and, when used at the appropriate therapeutic dose, are associated with at least 70% inhibition of plasma DPP-4 activity (35) (although the actual extent of inhibition in vivo is likely to be higher, due to dilution of the inhibitor in the ex vivo assay)

Greater weight loss efficacy of tirzepatide 10 mg ( 3.2 kg) and 15 mg ( 5.2 kg) compared to semaglutide was also observed in an indirect comparison with data from the SUSTAIN FORTE study, where semaglutide was administered at the maximum hypoglycemic dose of 2.0 mg [49]