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However, it is plausible that higher doses, leading to more rapid weight loss and faster drops in blood sugar, could theoretically increase the risk of indirect effects like TIND or nutritional deficiencies

We used version 2 of the Cochrane risk-of-bias tool (ROB 2) to assess the risk of bias, conducted frequentist random-effects network meta-analyses and evaluated confidence in effect estimates utilising the Confidence In Network Meta-Analysis (CINeMA) framework

It is unsuitable for people with type 1 diabetes, where it cannot replace insulin

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