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Conversely, inhibiting TLR4 can suppress microglial activation, alleviate neuroinflammation, improve cognitive function, and mitigate synaptic plasticity impairments and depression-like symptoms via this pathway (159, 160)

Thiamin deficiency has been linked to increased -amyloid production in cultured neuronal cells and to plaque formation in animal models (65, 66)

Unfortunately, this abusive use of anabolic-androgenic steroids has given testosterone replacement therapy a bad rap due to symptoms of too much testosterone and other chemicals in steroids