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In the phase 2 KEYNOTE-942 trial (NCT03897881), the combination of mRNA-4157, a personalized mRNA-based neoantigen vaccine, with pembrolizumab significantly enhanced RFS and DMFS relative to pembrolizumab monotherapy in patients with resected high-risk stage IIIBIV melanoma

Glutathione, a major intracellular non-protein thiol, protects against free radical damage by providing reducing equivalents for several key antioxidant enzymes