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GLP-1 receptor agonists are FDA-approved for two primary indications: type 2 diabetes management and chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity

GLP-1 medications GLP-1 medications may help people safely lose about two-thirds of their post-surgery weight regain, research suggests

however, in the metabolic context created by concurrent GLP-1 and GIP activation (which provides the insulin response to counterbalance glucose effects), glucagon receptor activation primarily drives hepatic fat oxidation, increases resting energy expenditure, and promotes lipolysis from adipose tissue

FIGURE 11 Molecular docking Ten targets (AKT1, TNF, SRC, EGFR, JUN, VEGFA, CND1, MAPK3, MAPK1, and CREB1) were chosen according to the results of the PPI network as the core targets of FRP for the treatment of AD