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The whole is greater than the sum of its parts

What is the ultimate molecular switch that determines whether NRF2 acts as a cytoprotective factor or a tumor promoter in different disease contexts

H.et al (2009)

Free Radic Biol Med 41:16941703 Boyd-Kimball D, Sultana R, Abdul HM, Butterfield DA (2005) Gamma-glutamylcysteine ethyl ester-induced up-regulation of glutathione protects neurons against Abeta(1-42)-mediated oxidative stress and neurotoxicity: implica-tions for Alzheimers disease