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occasional reports of mild headache, transient jitteriness, or injection-site reactions

Receptor endocytosis is crucial for signal transduction, either clathrin-dependent or independent (Sorkin and von Zastrow, 2009

ACSL4 catalyzes the reaction of PUFAs to polyunsaturated fatty acid-coenzyme A (PUFA-CoA), and then the PUFA-CoA undergoes esterification by lysophosphatidylcholine acyltransferase 3 (LPCAT3) to become polyunsaturated fatty acid-phospholipids (PUFA-PLs), which are then oxidized by reactive oxygen species (ROS) to cytotoxic phospholipid hydroperoxides (PL-OOH), leading to cell death through membrane modification (Zhang et al., 2025a

consumer guidance echoes this point (see GoodRxs explainer on clearance )