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Some patients are naturally less responsive to incretin-based therapies, though this represents a minority of cases

Sources Eli Lilly press release via PR Newswire/Morningstar

Melanin production occurs in specialized cells called melanocytes

16 To examine whether adaptive immune compensation in response to the increased gut permeability in these mice may have affected the overall phenotype, investigators examined the susceptibility of F11r(/)Rag1(/) mice to acute colitis