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IGF-1 LR3 research typically starts at 20 mcg daily and rarely exceeds 40 mcg in human-equivalent animal models, because the reduced IGFBP binding makes even low doses highly bioavailable

Although both type 1 and 2 5 -reductases are expressed in prostate tumor cells 28 , and the administration of 5 -reductase inhibitor alone or in combination with androgen antagonist inhibits prostate tumor cell growth in culture 88 , 89 , the efficacy of finasteride in the treatment of prostate cancer is disappointed 90

In addition, SLC1A5 was shown to have clinical importance, and it is considered the most critical plasma membrane glutamine transporter in cancer cells 201