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Roche announced today positive topline results from two arms of an ongoing multi-part Phase I clinical trial for CT-996, an investigational, once-daily, oral small molecule GLP-1 receptor agonist being developed for the treatment of both type 2 diabetes and obesity

Glyphosate , which is the herbicide in RoundUp, changes the gut microbiome in a way that reduces GLP-1 production.[ref] Glyphosate is abundant in the environment and is now found in almost everyones bloodstream

Additional monitoring considerations include assessing for symptoms of pancreatitis (severe, persistent abdominal pain), gallbladder disease (right upper quadrant pain, fever), or diabetic retinopathy changes

References 6B3J: Liang YL, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Truong TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang MW, Miller LJ, Christopoulos A, Sexton PM, Wootten D