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Increased levels of both oxidants and lipid peroxidation products, such as 8-isoprostane, have been detected consistently in the exhaled breath condensate of patients with COPD, along with significantly elevated levels of HNE and its adducts by at least 50% in the airway and alveolar epithelial cells, endothelial cells, and neutrophils of COPD patients [130,131]

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