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The tail that wags the dog: how the disordered C-terminal domain controls the transcriptional activities of the p53 tumor-suppressor protein

The traditional approach, where individual departments run ad-hoc pilots with AI vendors, is slow, inconsistent, and rarely leads to scaled deployment

These data illustrate how the enzymatic action of GPx-1 links it to the intracellular GSH/GSSG redox couple transferring redox stress in the cell to the easily restored GSSG rather than reactive protein thiols (189, 196)