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Tender point sensitivity may also begin to improve during this period, with some patients noting they can tolerate light touch or pressure that previously caused significant discomfort

Discontinue RYBELSUS in women at least 2 months before a planned pregnancy due to the long washout period for semaglutide Lactation: A clinical lactation study reported semaglutide concentrations below the lower limit of quantification in human breast milk

It is often a first-line treatment due to its efficacy and generally manageable side effects

Reconstitution considerations Most semaglutide-niacinamide compounds come pre-mixed from the pharmacy in ready-to-inject liquid form