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Although this risk has been observed in animal studies, its not yet confirmed in humans

Examples of the non-polar interactions between side chains atoms of GLP-1 and the receptor protein include His7 of GLP-1 forming a hydrogen bond with Gln234 of the receptor

Nat Rev Drug Discov 21(3):201223 Kanoski SE et al (2011) Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4

The effect of body mass index on glucagon-like peptide receptor gene expression in the post mortem brain from individuals with mood and psychotic disorders