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AL 082D06 - CAS# 256925-03-8 043 5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea

SKU: 18560043699

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AL 082D06 - CAS# 256925-03-8 043 5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)ureaAL 082D06, CAS No. 256925 03 8, also known as D 06, is a nonsteroidal glucocorticoid receptor antagonist. AL082D06 binds specifically to GR with no measurable binding affinity to the progesterone receptor. AL082D06 binds with nanomolar affinity to the GR and has no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins. AL082D06 inhibits glucocorticoid mediated transcriptional

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Description

5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea

MDA-MB-435

Water: 100 mg/mL(136

JNJ-42041935 was used at 10 µM final concentration in vitro and in cellular assays

AL 082D06 - CAS# 256925-03-8 043 5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)ureaAL 082D06, CAS No. 256925 03 8, also known as D 06, is a nonsteroidal glucocorticoid receptor antagonist. AL082D06 binds specifically to GR with no measurable binding affinity to the progesterone receptor. AL082D06 binds with nanomolar affinity to the GR and has no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins. AL082D06 inhibits glucocorticoid mediated transcriptional

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