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By contrast, SLU-PP-332 does not reproduce mechanical loading, balance, motor learning, bone adaptation, cardiovascular conditioning, or the psychological benefits of physical activity

The latest study included nearly 100,000 participants, more than 20,000 of whom had used GLP-1 medications

There are a number of reasons for the frequent use of this therapy: from a pathophysiological point, the metformin/DPP-4 combination leads to higher GLP-1 concentrations compared to a therapy with a DPP-4 inhibitor alone (75)

Dose reduction may work for select patients, but complete discontinuation remains difficult without alternative therapies or a multidisciplinary approach