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TTM inhibits their uptake and delivery by chaperone proteins to downstream cuproenzymes, such as LOX, inducing functional defects in these enzymes [225]

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Rev Neurol (Paris) 172(1):313 Lokovic BV, Gottesman RF, Bernstein KE, Seshadri S, McKee A, Snyder H, Greenberg SM, Yaffe K, Schaffer CB, Yuan C, Hughes TM, Daemen MJ, Williamson JD, Gonzlez HM, Schneider J, Wellington CL, Katusic ZS, Stoeckel L, Koenig JI, Corriveau RA,, Chen J (2020) Vascular contributions to cognitive impairment and dementia (VCID): a report from the 2018 national heart, lung, and blood institute and national institute of neurological disorders and stroke workshop