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These mast cell mediators provoke potent inflammatory responses that can include urticaria (AKA hives-skin rash and swelling), angioedema (swelling beneath the skin surface), bronchoconstriction (airway constriction), diarrhea, vomiting, hypotension (low blood pressure), cardiovascular collapse, and death, all within a matter of minutes

Glycine is the smallest amino acid, and its presence in GHK-Cu gives the peptide a broad, flexible affinity for many tissue types, including skin, connective tissue, and blood vessel walls

The first receptor target is GLP-1, or glucagon-like peptide-1

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