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The RNA-Seq study of brain tissues of Nothobranchius guentheri, which received meclofenoxate for almost a lifetime, concluded that while meclofenoxate compensated for age-dependent downregulation of neuronal activity genes, its effect on the aging brain transcriptome still could not be considered unequivocally positive [56]

Old age-associated phenotypic screening for Alzheimers disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa

Well-regulated interactions between these discrete immune cell populations, as well as with the enteric nervous system, intestinal walls, and the gut microbiota, are critical for proper gut homeostasis, and disruptions in these interactions play important roles in numerous gut diseases, including IBD