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Pharmacokinetic limitations should be addressed through advanced formulation strategies, including lipid-polymer hybrid nanoparticles, cyclodextrin inclusion complexes, and PEGylated micelles, to improve solubility, bioavailability, circulation time, and tissue targeting

10.1177/15353702231198087 100 KongL.WangH.LiC.ChengH.CuiY.LiuL.et al (2021)

The peptide's broad healing capabilities make it suitable for multiple concurrent issues, potentially replacing several targeted treatments

The ability of acyl-GIP to reduce food intake at the onset of the dark phase and in the 16-h fast-refeed paradigm was maintained in Gipr hypo-KO mice (Fig