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This synergy hypothesis that GIP and glucagon receptor activation potentiate each others metabolic effects when combined with GLP-1 is one of the most important pharmacological questions in modern metabolic research

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Conversely, ACSL4 expression, along with levels of ROS, MDA, 4-HNE, Fe 2+ , and -synuclein, were markedly elevated, thereby exacerbating ferroptosis and lipid peroxidation in the brain

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