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Mucolytics such as dornase alfa (NCT04402944, phase II of recombinant human DNase I for COVID-19) and mannitol (NCT00251056, phase II of mannitol for cystic fibrosis) have been tested mainly to relieve mucus blockages, but they do not assist drugs breakthrough or controllability interact with the mucus effectively

[DOI] [PMC free article] [PubMed] [Google Scholar] 103.Johari M.I., Yusoff K., Haron J., et al

With advancing age there is an accumulation of DNA mutations, and resultant metabolic dysfunction, which are both inherent involved in the aging process