EPZ015666 (GSK3235025) - PRMT5 Inhibitor. CAS# 1616391-65-1 size:10 mg solid increased blood hemoglobin and hematocrit
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EPZ015666 (GSK3235025) - PRMT5 Inhibitor. CAS# 1616391-65-1 size:10 mg solid increased blood hemoglobin and hematocritEPZ015666, also known as GSK3235025, CAS No. 1616391 65 1, is a potent and selective and orally active PRMT5 inhibitor with a half maximal inhibitory concentration (IC50) of 22 nM and broad selectivity against a panel of other histone methyltransferases. Treatment of MCL cell lines with EPZ015666 led to inhibition of SmD3 methylation and cell death, with IC50 values in the nanomolar range. Oral dosing with EPZ015666 demonstrated dose dependent
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