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In summary, the potential mechanism by which diabetes contributes to neurodegeneration in AD and PD may involve the accumulation of AGE and cellular IR

Topamax (topiramate) is an antiepileptic drug with a more complex and not fully understood mechanism of action

This finding underscores the critical importance of baseline ophthalmologic assessment and ongoing monitoring for patients with established retinopathy, particularly when initiating potent glucose-lowering therapies that can cause large and swift reductions in HbA1c