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Name: where is semaglutide metabolized targets MASH molecular pathways beyond weight loss Utilizing Semaglutide for Addressing Type-2
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This decreases nitric oxide (NO) bioavailability (31), elevates adhesion molecules like ICAM-1/VCAM-1 to facilitate leukocyte adhesion (leukostasis) (32), and disrupts tight junctions (such as occludin, ZO-1) through TGF- and VEGF signaling (3336)