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Other potential side effects of GLP-1 drugs include: Vomiting Constipation Dizziness Increased heart rate Upset stomach Fatigue Decreased metabolism Lower muscle mass Reduced bone density Vitamin and mineral deficiencies Among the less common side effects are: Low blood sugar (hypoglycemia) Medullary thyroid cancer Multiple endocrine neoplasia Acute pancreatitis Gallstone attacks Bile duct blockage Bowel obstruction Harvard Health Publishing points out that most side effects of GLP-1 drugs arent serious