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Similarly, agents such as Ex-4 and other GLP-1RAs suppress both amphetamine- and cocaine-induced conditioned place preference (Egecioglu et al., 2013a

From that standpoint, its probably more the variation in whats happening at the microbiome level as far as exposure to these compounds. Thats why the TMAO synthesis pathway has become one of the first gut microbiota targets for pharmaceutical interventions to prevent CVD,12 even though that pathway is quite complex