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The underlying molecular mechanisms involve direct ROS-induced oxidative damage to neuronal lipids, proteins and DNA [331], as well as ROS-mediated oxidative modifications that crucially promote the aberrant aggregation of toxic proteins [332]

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Treatment with L-Carnitine (300 mg/kg) and alpha-lipoic acid (100 mg/kg) for 28-30 days in aged rats restores activities of succinate dehydrogenase, malate dehydrogenase, -ketoglutarate dehydrogenase, isocitrate dehydrogenase, and respiratory complexes I-IV to near-normal levels, indicating enhanced mitochondrial energy-producing capacity