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Side Effects and Safety Considerations Like all stimulant medications, Vyvanse is not without side effects, but most are mild to moderate: Common side effects in children: Decreased appetite, insomnia, abdominal pain, irritability, headache, nausea Common side effects in adults: Dry mouth, insomnia, decreased appetite, anxiety, jitteriness Rare risks: Increases in heart rate and blood pressure were noted but were generally small and not clinically significant in most patients