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To prevent re-uptake of L-carnitine secreted from the E

This method (systematic review) has evolved over the last 20 to30 years and is widely and increasingly used to underpin clinical practice guidelines, Dr

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There are already frameworks to support this, such as NICE [National Institute for Health and Care Excellence] guidance for pain management and prescribing e.g., NG193 and NG215. Davies added that pharmacists should support patients and prescribers to better understand these risks and help to challenge the perception that gabapentinoids are low-risk options. In January 2026, the Medicines and Healthcare products Regulatory Agency announced warnings on the risk of dependency and addiction for gabapentinoids, benzodiazepines and z-drugs are to be strengthened, following a safety review by the regulator