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Food and Drug Administration, Vyvanse is classified as a central nervous system stimulant

Chronic treatment may reduce excitatory neurotransmission and contribute to neuroprotective effects by increasing glutamate uptake and reducing the increase in intracellular calcium through the activation of NMDA receptors [58]

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Escribano-Nunez A., Cornelis F.M.F., De Roover A., Sermon A., Cailotto F., Lories R.J., Monteagudo S