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Samita Garg, MD, associate professor of medicine at Cleveland Clinic Lerner College of Case Western Reserve University, and director of multidisciplinary gastroenterology endocrine GLP clinic in the department of gastroenterology, hepatology and nutrition at the Digestive Disease Institute, Cleveland Clinic Foundation, said the prevalence of overweight and obesity has been increasing among people with type 1 diabetes in recent years

Wegovy is FDA-approved for weight loss (and heart disease and MASH), and Ozempic is approved for type 2 diabetes, but is still often prescribed off-label for weight loss

Clinical effectiveness of currently used antidepressant drugs, which target monoaminergic systems in the brain mainly by enhancing serotoninergic and noradrenergic neurotransmission, is very often low and insufficient since approximately only one-third of the patients achieve complete remission of depressive symptoms after therapy

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