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Interestingly, MCTs appear to be altered early in patients at risk for developing AD since young asymptomatic adult carriers of the apolipoproteins E 4 allele (APOE4), who are at high risk for developing AD, have increased expression of MCT2 and decreased expression of MCT4 in posterior cingulate cortex, as measured by Western blot analysis (Perkins et al., 2016)

Weight loss caused a temporary increase in IGF-1 concentrations (P = .03) and continued decrements in blood glucose levels (P = .0004 at 16 weeks)

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