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The answer lies in the delivery

Dimethyl itaconate is effective in host-directed antimicrobial responses against mycobacterial infections through multifaceted innate immune pathways

However, there is one major drawback in this approach, which has significant implications for patient care and future directions in clinical research

The median OS was 16.4 months (95% CI, 13.9-18.4) with nivolumab versus 14.7 months (95% CI, 11.9-17.2) with sorafenib, which did not meet the prespecified threshold for statistical significance ( P = .0752)