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Animal experiments have shown that EGCG induced hepatotoxicity correlates with changes in several oxidative stress markers in the body, including MDA, 4-HNE, MT, H2AX, and Nrf2 (228, 229, 231, 235)

Additionally, clearance variability has been linked to bilirubin levels and postnatal age (198, 206)

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Since it is abundant in hypothalamus, it can affect the neuronal activity and thus hypothalamo-pituitary gonadal (HPG) axis to exert its impact on female reproduction [16]