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Retatrutide activates GLP-1 receptors, which slow gastric emptying food stays in the stomach longer, causing cramping, bloating, and pressure

GLP-1 is released in the intestinal tract upon food intake, regulates glucose homeostasis, and reduces appetite through peripheral and central mechanisms of action (Holst 2007)

39 The pre-specified primary objective of this meta-analysis was the comparison of the time to the first occurrence of confirmed 4-component MACEs (MACE-4) (i.e., cardiovascular death, myocardial infarction, stroke, and hospitalization for unstable angina) between the pooled tirzepatide and control groups